PKD1 gene mutation and ultrasonographic characterization in cats with renal cysts

Background: Polycystic kidney disease (PKD) has a complex phenotype partly explained by genetic variants related to this disease. Ultrasonography is promising approach for defining clinical signs. This study aimed assess characteristics in cats with Polycystin-1 (PKD1) gene mutations and wild-type cats. Kidney were identified ultrasonography. Methods: A total of 108 variable breeds aged an average 37.01±3.50 months included. Blood examination biochemical tests evaluated. For cystic formation, renal ultrasound was performed. The PKD1 mutation via polymerase chain reaction (PCR) DNA sequencing. Matrix correlation effectiveness detection determined. Results: The results showed that 19.44% had mutations, high prevalence Persian Persian-related breed Our demonstrated the kidneys mutations. Based on ultrasonography results, there association between cyst formation. findings indicated did not detect cysts 4-36 months, supporting evidence may be present. found sensitivity specificity heterozygous mutation. Moreover, formation increased risk 2,623 times compared normal kidneys. Conclusions: Ultrasonographic examination, coupled investigations, help clarify phenotypic variability PKD1. profile will guide therapeutic outcomes reduce PKD morbidity mortality cats.